A group of researchers, led by the Spanish Juan Carlos Izpisua of the Laboratory of Gene Expression of the Salk Institute of the United States, have taken a step closer to this scientific dream. It would be enough to use a cocktail of four gens to erase the signs of aging. The demostration, with mice and human cells, is presented in the magazine «Cell».
In addition to the US center, the research team has collaborated with the Catholic University of Murcia, the Center Clinic in Madrid, the Hospital Clínic in Barcelona and the University of Michigan School of Medicine.
With the treatment, the cells grown in the laboratory rejuvenated not only in appearance, but in its functioning. The effect was remarkable. The therapy was applied in two types of mice: in a model that reproduces progeria, a rare disease that in humans causes a premature and aggressive aging from birth, and in mice with a natural old age. In the former, treatment prolonged life by 30 percent. "If we transferred this figure to humans, we would be talking about 25 years in a person with a life expectancy of 80 years, although it is still very difficult to extrapolate this figure," Juan Carlos Izpisúa, lead author of the study, told ABC.
In normal mice, the strategy improved the repair capacity of the muscles and pancreas (these two organs were chosen, as others might have been chosen to see their recovery). "We believe that the rejuvenating effects will be observed in all tissues and organs because the molecular basis of aging are common. Mice are not human and we know that it will be much more complex to rejuvenate a person, "he acknowledges.
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Commentary:
In my opinion this type of discovery can bring a lot of positive tings to us but it's a large project that will sems results in a few years.
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